Live Yeast Cell Derivative (LYCD) or Biodyne for Puffy Eyes


Classified by the FDA as a wound-healing agent, LYCD (also called Biodyne), is a skin respiratory factor that helps skin cells to promote the healing process through the uptake of oxygen.

It was patented by Dr.Sperti in 1939, who named it Biodyne because it stimulates healthy cell growth. The word Biodyne comes from the Greek words bios (life) and dyne (force).

The theory of cell injury
When cells experience injury or destruction, some will produce hormones which stimulate cellular multiplication so that the tissues heal. It’s like a community picking up the pieces to help an individual in trouble. Dr Sperti’s group, who discovered Biodyne, found that they were able to isolate a ‘reproductive stimulating substance’ from the dead tissue. They were able to isolate three distinct substances:

  • Those that accelerate the cellular metabolism of sugar
  • Those that stimulate growth and reproduction
  • Those that stimulate cell reproduction.

Collectively, these substances were named Biodynes.

Further research at the University of Cininnati demonstrated that biodynes could be extracted from heated yeast cells. This type of biodyne is called Live Yeast Cell Derivative (LYCD) and contains nutrients such as proteins, amino acids, minerals, carbohydrates, nucleic acid and other gene products. The active ingredient has even been isolated as a protein fraction containing a mixture of several peptides one of which is a peptide fraction that stimulates wound healing. Biodyne is known to be biologically active on skin cells. Cinical studies from the Cincinnati Burn Unit and Oregon University School of Medicine show that Biodyne speeds wound healing in burns and post surgically.

Biodynes (LYCD) are also known as Skin Respiratory Factor and Tissue Respiratory Factor.

Can LYCD relieve puffy eyes?

Though not clinically proven, anecdotal evidence suggests that LYCD can help to relieve puffy bags under the eyes. And some individuals report a reduction wrinkles. Research will help to either consolidate or discount these claims. In the meantime, LYCD may be found in Preparation H, but only from Canada. The US version of preparation does not contain LYCD.

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Natalie tenny said,

July 27, 2008 @ 10:02 am

I have been reading about LYCD and Prep H and am really disappointed that the FDA has banned live yeast cell derivatives. What nonsense! Why doesn’t the FDA do something useful for us instead of putting up barriers???
I tried Botox one time, and later read about the side effects. I feel very fortunate that my eyelids did not droop, or that I did not die!
Let me know more about LYCD, please.

Sharmani said,

July 28, 2008 @ 1:16 pm

Hi Natalie

LYCD is a peptide – peptides are known for their wound healing properties as well as ability to boost collagen production.

Other peptide containing products that you may be interested in are:
Neostrata Wrinkle Repair (
UltimaSkin Alpha Lipoic Acid Serum (

Chantal said,

July 13, 2009 @ 2:08 am

I just bought some Prep. H with Biodyne, since I’ve heard it helps with puffy eyes and possibly dark cycles under the eyes as well. But now that I have the product, I’m worried I will use it incorrectly (since it originally isn’t made for this use, and the package doesn’t include instructions about applying it around the eyes). Do you have any advice in regards to the correct way to apply the cream around the eyes? How often should I apply it?
Thanks for your time and help!

Sharmani said,

September 9, 2009 @ 11:48 am

To Chantal

Customers who use the Preparation H apply it either once or twice daily. As with any new skin care product, it is wise to perform a patch test first to ensure that your skin tolerates the product.

Patty Tarbell said,

December 11, 2011 @ 3:31 pm

Is the effect cumulative or does it work topically?

Sharmani said,

December 12, 2011 @ 3:43 pm

For Patty: you wanted to know if the active ingredients in Canadian Preparation H act immediately to tighten sagging skin and wrinkles, or if the effect is cumulative. As it acts as a collagen booster, the LYCD in this product will take several weeks to support the intracellular connections which make for younger looking skin. So don’t expect immediate results! Thanks for asking, Sharmani

Sheila said,

June 5, 2013 @ 6:47 pm

I have been hearing that the Canadian Preparation H, not sure if it is gel or cream works for shrinking tummy fat. I am assuming if this work it must be temporary? They have been putting it on their belly, wrapping in plastic wrap then an ace bandage. Does this really work?

Sharmani said,

June 10, 2013 @ 2:12 pm

For Sheila:
That’s a new one for us! We haven’t heard of Preparation H being used to shrink tummy fat so, unfortunately, we’re not able to comment on whether it is effective or not.
Best, Sharmani


March 2, 2014 @ 12:01 pm

I am wondering about dosing. Preparation H with Bio-Dyne comes in 25g, 50g, and 75g. What is the lowest effective minimum dosage?

Sharmani said,

March 5, 2014 @ 11:51 am

For Judith,
Preparation H contains 1% BioDyne. Although this cream is manufactured in 25g, 50g and 75g tubes, we currently only carry the 50g size.
Best, Sharmani

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